PRP, or platelet rich plasma, has been revolutionizing many areas of medicine, from orthopedics to skincare. Hyaluronic acid as well has a wide range of applications serves as an excellent tool in biomedical applications such as osteoarthritis surgery, ocular surgery, plastic surgery, tissue engineering, and drug delivery.
Both PRP (Platelet Rich Plasma) and Hyaluronic Acid (HA) treatments have demonstrated their effectiveness on treated areas. While each treatment can be powerful on its own, it can be even more powerful when combined with both treatments. New research is showing incredible results from creating a mix of PRP and Hyaluronic Acid (HA) treatments, achieving a two-dimensional effect on the signs of focus areas.
Before get to understand more about the results of combining PRP With Hyaluronic Acid, we first need to understand each elements.
PRP (platelet-rich plasma) injection/therapy uses injections of a concentration of a patient’s own platelets to accelerate the healing of injured tendons, ligaments, muscles and joints. In this way, PRP injections use each individual patient’s own healing system to improve musculoskeletal problems.
PRP injections are prepared by taking anywhere from one to a few tubes of your own blood and running it through a centrifuge to concentrate the platelets. These activated platelets are then injected directly into your injured or diseased body tissue. This releases growth factors that stimulate and increase the number of reparative cells your body produces.
After creating platelet-rich plasma from a patient’s blood sample, that solution is injected into the target area, such as an injured knee. In some cases, the clinician may use ultrasound to guide the injection. The idea is to increase the concentration of specific bioproteins or hormones, called growth factors, in a specific area to accelerate the healing process.
Hyaluronic acid (HA) is a humectant, is a gel-like substance that naturally occurs in the body, and it attracts and absorbs water like a sponge and works to cushion and hydrate joints, nerves, eyes, hair and skin. This substance is naturally found in many areas of the human body, including the skin, eyes, and synovial fluid of the joints.
As we age, the production of key substances in the skin, including hyaluronic acid (along with collagen and elastin) decreases. As a result, our skin loses volume, hydration, and plumpness.
Hyaluronic acid is a natural substance found in the fluids in the eyes and joints. It acts as a cushion and lubricant in the joints and other tissues.
Different forms of hyaluronic acid are used for cosmetic purposes. Hyaluronic acid might also affect the way the body responds to injury and help to decrease swelling.
Hyaluronic acid injections are US FDA-approved for several conditions, including cataracts, osteoarthritis, and as an injectable gel filler for facial wrinkles. People also commonly take hyaluronic acid by mouth and apply it to the skin for UTIs, acid reflux, dry eyes, wound healing, aging skin, and many other conditions.
Many studies have shown the effectivness of each treatment on its own. When comparing PRP and Hyaluronic Acid, studies show that PRP is better. However, recent studies suggests that adding both in the same injection is even better. They compared people who had combined PRP and hyaluronic acid to those who had just hyaluronic acid. At 3, 6, and 12 months, there was a big difference in favor of the combined injection. Another study compared this dual therapy with PRP alone and found a similar result with improved pain scores at 12 months.
By creating a mix of PRP and Hyaluronic Acid (HA), you can achieve a two-dimensional effect on the treated areas. HA works to increase the levels of moisture in the underlying layers while PRP works to rejuvenate the layer of collagen and elastin. Together, PRP with HA provide better results.
Here is a study that evaluate the effectiveness and explore the therapeutic mechanisms of platelet-rich plasma (PRP) combined with hyaluronic acid (HA) as a treatment for knee osteoarthritis (KOA).
In the study, there are total of 122 knees were randomly divided into HA (34 knees), PRP (40 knees), and PRP+HA (48 knees) groups. The platelet density in PRP was 5.13-times that in whole blood (P = .002). At 24 months, pain and function scores in the PRP+HA group were better than those in the HA-alone and PRP-alone groups (Ppain = .000; Pfunction = .000). At 6 and 12 months, synovial hyperplasia in the PRP and PRP+HA groups was improved (P < .05). After 6 and 12 months, the synovial peak systolic velocity, synovial end-diastolic velocity, systolic/diastolic ratio, and resistance index were improved in the PRP+HA group (P < .05). Complications were greatest in the PRP group (P = .008). After 6 and 12 months, interleukin-1β, tumor necrosis factor-α, matrix metalloproteinase-3, and tissue inhibitor of metalloproteinase-1 in the PRP and PRP+HA groups decreased (P < .05), with more apparent inhibition in the PRP+HA group (P < .05).
In conclusion, PRP combined with HA is more effective than PRP or HA alone at inhibiting synovial inflammation and can effectively improve pain and function and reduce adverse reactions. Its mechanism involves changes in the synovium and cytokine content.
Here is another study that demonstrates the effectiveness of the PRP with hyaluronic acid injections for face rejuvenation and focus on developing a standardized procedure for PRP preparation to its efficacy and potency.
A series of 94 female patients with varying degrees of facial aging signs were treated with PRP and hyaluronic acid (HA). Mean age was 53.0 ± 5.6. The mean injection number was 3.6 ± 2.0. Platelet-poor and platelet- rich plasma parts were mixed with 0.5 cc %3.5 hyaluronic acid and 0.5 cc procaine and injected with a 30G, 13-mm needle into deep dermis and hypodermis. Patients were asked to rate their personal satisfaction with their skin texture, pigmentation, and sagging. In addition, the overall results were rated by three independent physicians and the patients themselves. The outcomes were peer-reviewed, and correlations between the degree of the aesthetic scores and the number of injections were explored.
There was a statistically significant difference in general appearance, skin firmness-sagging and skin texture according to the patients’ before and after applications of PRP with HA. A statistically significant correlation was found between the number of injections and overall satisfaction.
In conclusion, the PRP and HA injections provided clinically visible and statistically significant improvement on facial skin. The improvements were more remarkable as the injection numbers increased.
Case studies show that PRP and Hyaluronic Acid treatments are certainly effective individually. However, a combination of the two therapies has shown more impressive results. Using other variables, doctors can help achieve better outcomes. Therefore, we can conclude that by PRP with Hyaluronic Acid tube will create even better effectiveness/results.
Hair loss can be a challenging experience, affecting self-confidence and overall well-being. Among the many solutions available, PRP treatment for hair loss has emerged as a revolutionary option. This natural, non-surgical procedure harnesses the healing properties of your own blood to stimulate hair regrowth. Here, we’ll delve into the benefits,
Platelet-Rich Plasma (PRP) therapy has gained significant popularity in the field of regenerative medicine. To ensure the viability and effectiveness of PRP, the choice of additives in the PRP tube is crucial.
Nos pondremos en contacto con usted lo antes posible.
