Hair loss with peptides: The disease target for prevention or treatment with the pharmaceutical composition “alopecia” refers to the absence of hair in an area where hair should normally be present. Specifically, it may refer to the loss of hair formation (thick black hair) on the scalp. The causes of hair loss are not limited, but can be caused by genetic factors, hormonal imbalances, mental stress, exposure to air pollution, consumption of processed foods, and environmental influences. For instance, hair loss includes hereditary androgenetic alopecia (male or female pattern baldness), circular alopecia, tinea capitis caused by fungal infections, alopecia areata, trichotillomania, hair growth disorders, and scarring alopecia, which can refer to hair loss caused by lupus, folliculitis, lichen planus, burns, and trauma.

According to one embodiment, hair loss with peptides shows the effect of promoting the proliferation, activity, or growth of hair follicle cells, inhibiting the apoptosis of hair follicle cells, and inhibiting the expression of hair loss-related factors. Therefore, hair loss with peptides may be used as an active ingredient in a pharmaceutical composition for the prevention or treatment of hair loss.

Beneficial effects of hair loss with peptides include:

a. Inhibiting the apoptosis of hair follicle cells and inhibiting the expression of hair loss-related factor (DKK-1), which can improve, prevent or treat hair loss.

b. Promoting hair growth by promoting the activity, proliferation, or growth of hair follicle cells.

c. Hair loss with peptides can be included in cosmetic compositions or pharmaceutical compositions as active ingredients used to improve hair loss or promote hair growth, depending on the peptide.

Hair loss with peptides: The term “hair growth promotion” used in this instruction manual refers to all actions that increase hair growth in hair follicles and may also refer to all actions that increase the total amount of hair, such as promoting the proliferation, activity, or growth of hair follicle cells. Hair loss with peptides and the role of peptides in alopecia: Traditional functional peptides have effective biological activity, but their size can prevent effective introduction into targeted tissues or cells, or they may have a short half-life and quickly disappear from the body. However, hair loss with peptides includes a cosmetic composition with a peptide consisting of 10 or fewer amino acids as the active ingredient. This peptide has excellent skin permeability, and when topically applied, can effectively prevent hair loss and promote hair growth. Description of alopecia and improvement with peptides: The term “improvement” used in this specification refers to all actions that at least reduce the parameters (e.g., severity of symptoms) associated with the remission or treatment of the condition. The term “cosmetic effective dose” used in this instruction manual means an amount sufficient to achieve the alopecia improvement or hair growth effect of the cosmetic composition.

Hair loss with peptides promoting hair growth: The term “promoting hair growth” may refer to all actions that increase the growth of hair in hair follicles and increase the total amount of hair. Peptides can promote the activity of dermal papilla cells, hairblast cells, or outer root sheath cells, and also promote the proliferation mechanism of dermal papilla cells, inhibit the apoptosis of dermal papilla cells, and inhibit the expression of hair loss-related factors. Therefore, peptides can be used as active ingredients in cosmetic compositions to improve hair loss or promote hair growth, particularly in our follicle roots.